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Colorectal cancer gene methylation detection 'more preferred

Dual biomarkers which improve the detection sensitivity of left-sided and right-sided colon cancer. Fast operation time (4.5 hours) for 96 samples.The detection sensitivity for advanced adenoma is 63.4%.

Sensitivity 95.3%

Specificity 90.3%

Significance of early detection of colorectal canc

Early screening, high cure rate

Colorectal cancer is called 'lazy cancer' and develops relatively slowly. Early screening of colorectal cancer allows timely and effective intervention and treatment, and the five-year survival rate can reach over 95%.

Late detection, high medical costs

Colorectal cancer has no obvious symptoms in the early stage. Due to the lack of screening awareness, 85% of patients are found in the late stage, and the average medical cost is 200,000-300,000, which affects family happiness.

High Morbidity And Mortality

Data show that the number of cases worldwide is 1.93 million and the number of deaths is 940,000. In China, the incidence of colorectal cancer ranks second in new cancers.

Expert advice: 'Start at age 40, and have bowel cancer screening every 1-3 years'

Significance of early detection of colorectal canc

Detection principle

01

The occurrence of early tumors is often accompanied by specific DNA methylation abnormalities;

02

Intestinal tumor cells enter the intestine after shedding and are excreted in the feces, so specific colorectal cancer methylated DNA can be detected in the feces

03

Based on the molecular dimension, fecal DNA is extracted to understand colorectal cancer precancerous diseases, precancerous lesions, early cancers, cancers, and post-treatment monitoring by detecting abnormal DNA methylation levels.

Expert recommendation: Fecal DNA methylation detection is one of the detection methods for high-risk groups of colorectal cancer, and as a primary screening method before colonoscopy, It is more suitable for CRC high-risk people in the world.

Source: "Expert Consensus on Early Diagnosis and Screening Strategies for Colorectal Tumors in China"

Product advantages

The combined detection of the two targets can comprehensively increase the detection sensitivity of left and right colon cancers to 95.3%, avoiding missed diagnosis, while maintaining a high specificity of 90.3%, and increasing the detection sensitivity of advanced adenomas to 63.4%.

Aichangkang® reduces the sample suspension required for detection to 1.8 ml through patented micro signal enrichment technology (AS-CAP) and PCR sensitization technology, which requires less laboratory equipment and is more suitable for rapid completion in medical scenarios high-throughput detection tasks.

Aichangkang® can be carried out in the departments of digestion, anorectal, physical examination, oncology, etc. in general hospitals or specialized hospitals, and can also be used in out-of-hospital physical examination institutions and home self-tests of target users.

Aichangkang® has carried out technical optimization in several key steps such as sample pretreatment, nucleic acid extraction, nucleic acid conversion, PCR detection, etc. and process automation. A single sample detection can be completed in 4.5 hours, and a maximum of 96 samples can be processed each time.